The FountainTRT Enclomiphene Program

Fountain Vitality -

Enclomiphene is an oral medication designed to help men increase their natural testosterone production by stimulating the body's own hormonal pathways. Unlike traditional testosterone replacement therapy (TRT), which introduces external testosterone into the body, enclomiphene works by signaling the brain to increase the production of hormones (LH and FSH) that tell the testes to produce more testosterone naturally.

At Fountain, enclomiphene therapy is commonly used by men who want to optimize testosterone while maintaining fertility, avoiding testicular shrinkage, and supporting overall hormonal balance.

How Enclomiphene Works


Enclomiphene is a selective estrogen receptor modulator (SERM) designed specifically to raise testosterone by stimulating the body’s natural hormone signaling. It is not the same as Clomid (clomiphene citrate). Clomid contains a mix of two isomers (enclomiphene and zuclomiphene), but only enclomiphene is responsible for the testosterone-boosting effects, while zuclomiphene may cause unwanted estrogenic side effects.

Enclomiphene works by blocking estrogen receptors in the hypothalamus, which prompts the brain to increase luteinizing hormone (LH) and follicle-stimulating hormone (FSH), signaling the testes to produce more testosterone and sperm naturally.

Who Is Enclomiphene For?


Enclomiphene is typically considered for men who:

  • Have symptoms of low testosterone
  • Want to raise testosterone without suppressing fertility
  • Prefer a natural, internal stimulation of hormone production instead of external testosterone

It can be used as a standalone therapy or, in some cases, alongside other treatments depending on individual goals and medical circumstances.

Typical Benefits

  • Boosts natural testosterone production by stimulating the brain-to-testes signaling pathway.
  • Supports energy, motivation, mood, and mental clarity.
  • Improves muscle development, metabolism, and fat reduction.
  • Enhances libido, sexual function, and overall vitality.
  • Helps preserve fertility and testicular function by maintaining the hormones responsible for sperm production and natural testosterone output.
  • Avoids the use of external testosterone, reducing the risks of testicular shrinkage, fertility suppression, and other common side effects of traditional TRT.

Typical Dosing


With FountainTRT's Enclomiphene Therapy Program:

  • The typical dose ranges from 6.25 mg to 25 mg taken daily, depending on lab results and individual response.
  • The goal is to gently and consistently stimulate your natural testosterone production without overwhelming the hormonal axis.

Dosing is customized based on your baseline testosterone levels, goals, and overall health profile.

Typical Results and Timeline


Enclomiphene is not an instant-acting medication. Most men begin noticing benefits such as improved energy, mood, libido, mental clarity, and physical performance within 4 to 6 weeks, though this can vary.

Regular lab monitoring is important to assess how your body is responding and whether adjustments are needed.

Storage Recommendations

  • Store in a cool, dry place away from heat and direct sunlight (e.g., medicine cabinet).
  • Keep the container tightly sealed when not in use.

Potential Side Effects

Most men tolerate enclomiphene well, but possible side effects can include:

  • Headache
  • Mood changes or irritability
  • Gastrointestinal discomfort (nausea, cramping)
  • Mild nipple sensitivity or water retention
  • Rare visual disturbances (e.g., light flashes, floaters)

If visual symptoms occur, it is recommended to discontinue use and consult a healthcare professional.

Contraindications

Enclomiphene is not appropriate for:

  • Individuals with allergies to enclomiphene or similar compounds
  • Those with a history of hormone-sensitive cancers
  • People with untreated severe liver conditions
  • Individuals with uncontrolled cardiovascular risks or clotting disorders

Warnings and Precautions

  • As a SERM, enclomiphene impacts estrogen pathways, which is why ongoing monitoring of hormones is important.
  • Those with a history of blood clots, stroke, cardiovascular disease, or liver dysfunction should consult with a provider to assess whether enclomiphene is safe for them.
  • Overuse or incorrect dosing can disrupt hormone balance.
  • Not for Use in Women or Children

Black Box Warning

  • Enclomiphene is a SERM and may influence estrogenic activity in the body.
  • Use with caution if you have:
      • A history of blood clots or stroke
      • Cardiovascular disease
      • Liver dysfunction

Special Considerations

  • Compounded Medication Notice: Enclomiphene is a custom-compounded preparation made specifically for each patient.
  • Keep Out of Reach: Store away from children and pets.
  • Pre-Existing Conditions: Notify your provider if you have liver issues, pituitary disorders, or other hormonal conditions.

See If You Qualify for Treatment


You can get your testosterone levels tested and speak with a licensed medical provider with Fountain's Personalized TRT Evaluation. Get started here.

Contact Information

For any questions or concerns about this medication, please contact Fountain at support@fountain.net or call us at +1 (213) 237-1454 or text us at +1 (833) 967-3100.